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Contraindications, Drug Interactions, and Monitoring Important precautions include: Avoiding use in active, untreated malignancies due to theoretical tumor-promotion concerns Using caution with immunosuppressants Monitoring blood pressure and liver enzymes if treatment exceeds six weeks Consulting a healthcare professional if you have bleeding disorders or take anticoagulants Bodybuilders who use multiple compounds should be especially careful because side effects and interactions may be harder to identify

[12] [13] B12 works synergistically with folate (vitamin B9) in the methylation cycle, a biochemical pathway crucial for cell division and gene expression

These are also situations where you may need more injections than usual

That means vegans and vegetarians may respond well to B12 supplements or injections