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Doses above 10 mg daily and treatment duration exceeding two weeks amplify hyperglycemic effects considerably

Clinical studies show that GLP-1 receptor sensitivity declines gradually over 12-24 months, and weight loss velocity naturally decreases as you approach a new metabolic set point

A study involving 1,961 such individuals, published last year in the New England Journal of Medicine, found that those taking semaglutide lost an average of 14.9 percent of their initial body weight over 68 weeks, compared with one who received a placebo injection