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Musculoskeletal and Structural Concerns Acromegaly-like Symptoms: Abuse or high-dose use can lead to abnormal, irreversible soft tissue and bone growth

However, most studies are based on the analysis of stool microbiota which may not be fully representative of the small intestinal microbiota which can translocate through the intestinal barrier

They have been used in clinical medicine for decades

The biological rationale is that the body's healing program is itself coordinated, so supporting cell migration and local repair signaling together, rather than in isolation, is intended to better match how tissue actually rebuilds