WEHI-345 - CAS# 1354825-58-3 205 KU-55933 completely abrogates rapamycin-induced feedback

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WEHI-345 - CAS# 1354825-58-3 205 KU-55933 completely abrogates rapamycin-induced feedbackWEHI 345, CAS No. 1354825 58 3, is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production. WEHI 345 delays RIPK2 ubiquitylation and NF B activation downstream of NOD engagement. Despite only delaying NF B activation on NOD stimulation, WEHI 345 prevents cytokine production in vitro and in vivo and ameliorates experimental autoimmune encephalomyelitis in mice. Product information CAS

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