p53 Polyclonal Antibody, 20ul[BT-AP06825] Recombinant Protein Expression and represses their transcriptional activity

and represses their transcriptional activity

Several transcript variants encoding two different isoforms have been found for this gene

Alternatively spliced transcript variants encoding multiple isoforms have been observed for ITCH

The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs)

p53 Polyclonal Antibody, 20ul[BT-AP06825] Recombinant Protein Expression and represses their transcriptional activityTP53 encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The tumor protein p53 responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li Fraumeni syndrome.