Romidepsin Catalog No.:M8157-10 p53 is not enzymatically degraded

p53 is not enzymatically degraded and the transcriptional activity of p53 is restored

Free Radic Res

which has antitumor activities by inhibition of mitochondrial complex I

with an average cytostatic IC50 of >60 microM in 15 cell types

Romidepsin Catalog No.:M8157-10 p53 is not enzymatically degradedRomidepsin, also known as FK228; is a bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum with antineoplastic activity. After intracellular activation, romidepsin binds to and inhibits histone deacetylase (HDAC), resulting in alterations in gene expression and the induction of cell differentiation, cell cycle arrest, and apoptosis. This agent also inhibits hypoxia induced angiogenesis and depletes several heat shock