IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 CX-4945 exhibits a broad spectrum

CX-4945 exhibits a broad spectrum of antiproliferative activity

Characterisation of a Tip60 specific inhibitor

S3I-201 inhibits breast carcinoma MDA-MB-435

InChi: InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10

IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 60276 CX-4945 exhibits a broad spectrumIDH C227, CAS No. 1355324 14 9, is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0. 1 M, and 2 HG production in HT1080 and U87MG cells with IC50 < 0. 25 M. Because the mutated form of IDH1 produces the metabolite, 2 hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of