ARRY-520 (R) 30002 ZSTK474 blocks VEGF-induced cell migration

ZSTK474 blocks VEGF-induced cell migration and the tube formation in human umbilical vein endothelial cells (HUVECs)

Devereux S

PubMed PMID: 24403055

SB-431542 was intraperitoneally dosed to mice at 10 mg/kg once per day

ARRY-520 (R) 30002 ZSTK474 blocks VEGF-induced cell migrationARRY 520 R enantiomer is the R form of ARRY 520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor. ARRY 520 had low nanomolar antiproliferative activity in tumor cell lines and specifically inhibits KSP (kinesin 5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during the mitotic phase, and consequently cell death in tumor cells that are actively dividing. Product