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CCT251545 - CAS# 1661839-45-7 050 5-a]pyrimidine-3-carbonitrile
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CCT251545 - CAS# 1661839-45-7 050 5-a]pyrimidine-3-carbonitrileCCT251545, CAS No. 1661839 45 7, is a potent small molecule inhibitor of WNT signaling with good oral pharmacokinetics. CCT251545 is a potent and selective chemical probe for the human Mediator complex associated protein kinases CDK8 and CDK19 with >100 fold selectivity over 291 other kinases. In contrast to type II inhibitors of CDK8 and CDK19, CCT251545 displays potent cell based activity. CCT251545 alters WNT pathway regulated gene expression and
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