NVP-BSK805 Catalog No.:M7922-10 Smiles: CC1=CC(OCCOC2=CC(=CC=C2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C2C3=CC(Cl)=C(C=C3OC3=CC(=O)C(Cl)=CC3=2)OCOC(C)=O)=C(C=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O

Smiles: CC1=CC(OCCOC2=CC(=CC=C2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C2C3=CC(Cl)=C(C=C3OC3=CC(=O)C(Cl)=CC3=2)OCOC(C)=O)=C(C=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O

InChi: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7

inhibition of cohesin release from chromosome arms

CAS Number: 23279-22-3

NVP-BSK805 Catalog No.:M7922-10 Smiles: CC1=CC(OCCOC2=CC(=CC=C2N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=O)C2C3=CC(Cl)=C(C=C3OC3=CC(=O)C(Cl)=CC3=2)OCOC(C)=O)=C(C=C1)N(CC(=O)OCOC(C)=O)CC(=O)OCOC(C)=ONVP BSK805 is a JAK2 inhibor, which displays more than 20 fold selectivity towards JAK2 in vitro, as well as excellent selectivity in broader kinase profiling. In vivo, NVP BSK805 exhibited good oral bioavailability and a long half life. The inhibitor was efficacious in suppressing leukemic cell spreading and splenomegaly in a Ba F3 JAK2(V617F) cell driven mouse mechanistic model. Furthermore, NVP BSK805 potently suppressed recombinant human