IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosis
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IOX4 - PHD2 Inhibitor. CAS# 1154097-71-8 0154 Induction of the lysosomal apoptosisIOX4, CAS No. 1154097 71 8, is a potent and selective PHD2 inhibitor with IC50 ~1. 6 nM. It inhibits PHD2 via binding to the 2OG binding site, displays >1, 000 fold selectivity for PHD2 over other 2OG dependent dioxygenases, including JMJD isoforms, FBXL11, JARID1C, BBOX1, FIH, and FTO. IOX4 is active in vivo, inhibiting prolyl hydroxylation and increasing HIF 1 levels in cells (IC50 ~5. 6 11. 7 M) and inducing HIF 1 and HIF 2 expression in mice. The
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