Regorafenib Hydrochloride - CAS# 835621-07-3 Catalog No.:M10444-10 β-secretase 1 inhibitory activity and

β-secretase 1 inhibitory activity and AMP-activated protein kinase activation of Callyspongia samarensis extracts

InChi: InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2

1314890-29-3

000-fold selectivity against all other HDAC isoforms (IC50 >16 μM)

Regorafenib Hydrochloride - CAS# 835621-07-3 Catalog No.:M10444-10 β-secretase 1 inhibitory activity andRegorafenib (Stivarga, BAY 73 4506) Hydrochloride is a multi target inhibitor for VEGFR1, Murine VEGFR2 3, PDGFR, Kit (c Kit), RET (c RET) and Raf 1 with IC50 of 13 nM, 4. 2 nM 46 nM, 22 nM, 7 nM, 1. 5 nM and 2. 5 nM, respectively. Product information CAS Number: 835621 07 3 Molecular Weight: 519. 28 Formula: C21H16Cl2F4N4O3 Synonym: BAY73 4506 hydrochloride Chemical Name: 4 [4 ({[4 chloro 3 (trifluoromethyl)phenyl]carbamoyl}amino) 3 fluorophenoxy] N