E6446 oxyguanosine LD50: Mice 55mg/kg (i

LD50: Mice 55mg/kg (i

BIBW2992 is currently undergoing Phase III clinical trials for non-small cell lung carcinoma (NSCLC) and breast cancer

c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun

Chemical Name: 6H-Thieno[3

E6446 oxyguanosine LD50: Mice 55mg/kg (iE6446 inhibits Toll like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine phosphate guanidine (CpG) containing DNA, which stimulates TLR9. Product information CAS Number: 1219925 73 1 Molecular Weight: 449. 59 Formula: C27H35N3O3 Synonym: E 6446 Chemical Name: 6 [3 (pyrrolidin 1