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In neurodegenerative states, these mechanisms converge to restore synaptic plasticity via BDNF/TrkB signaling (Fig

47 Because of the high prevalence of frailty and sarcopenic obesity in the HFpEF population, future studies are required to estimate the proportion of lean body mass loss versus fat loss on GLP-1 RA therapy to identify predictors of the disproportionate loss of muscle mass