Netupitant metabolite Monohydroxy Netupitant ilin In absence of orthosteric agonist

In absence of orthosteric agonist

resulting in its trafficking through HDAC6 to perinuclear aggresomes without cytokine stimulation or SOCS-1 induction

BX-795 produces inhibitory effect on 2-MeSADP-induced or collagen-induced aggregation

2018 Jul 20

Netupitant metabolite Monohydroxy Netupitant ilin In absence of orthosteric agonistMonohydroxy Netupitant is the metabolite of Netupitant which is a potent and selective neurokinin 1 receptor (NK1) receptor antagonist. It is achiral and orally active. Product information CAS Number: 910808 12 7 Molecular Weight: 594. 59 Formula: C30H32F6N4O2 Synonym: Monohydroxy Netupitant Chemical Name: 2 [3,5 bis(trifluoromethyl)phenyl] N {4 [2 (hydroxymethyl)phenyl] 6 (4 methylpiperazin 1 yl)pyridin 3 yl} N,2 dimethylpropanamide Smiles: