GSK-J1 lithium salt ethyl Ivabradine Hydrochloride 1186/1471-2474-14-344

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GSK-J1 lithium salt ethyl Ivabradine Hydrochloride 1186/1471-2474-14-344GSKJ1 is a selective and potent histone demethylase inhibitor (GSK J1) that has significant activity (IC50 60 nM for human JmjD3) in vitro and in cells using an ester derivative (GSK J4: 1 M < IC50 < 10 M; e. g. 9 M in primary human macrophages). The pyridine regio isomer GSK J2 displays significantly less on target activity (IC50 > 100 M for human JmjD3) and thus can be used as control for target effects in vitro, and as ester derivative (GSK J5) in

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