CEP-32496 nhibitor (racemic) InChi: InChI=1S/C5H4N6O3S

InChi: InChI=1S/C5H4N6O3S

Epub 2013 Sep 16

2Na/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27

InChi: InChI=1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H

CEP-32496 nhibitor (racemic) InChi: InChI=1S/C5H4N6O3SAgerafenib, also known as RXDX 105, CEP 32496 and AC013773, is an orally available v raf murine sarcoma viral oncogene homolog B1 (B raf) serine threonine protein kinase inhibitor with potential antineoplastic activity. CEP 32496 specifically and selectively inhibits the activity of the mutated form (V600E) of B raf kinase. This inhibits the activation of the RAF mitogen activated protein kinase kinase (MEK) extracellular signal related kinase (ERK)