AZ5104 - CAS# 1421373-98-9 308 20 min before testing) decreased

20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval

10 nM and 60 nM

The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro

There is no formal name yet

AZ5104 - CAS# 1421373-98-9 308 20 min before testing) decreasedAZ5104, CAS No. 1421373 98 9, is a demethylated metabolite of AZD 9291. AZ 5104 was identified to exhibit 5 fold potency compared to AZD 9291, which is currently in clinical trial. AZ5104 is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Product information CAS Number: 1421373 98 9 Molecular Weight: 485. 58 Formula: C27H31N7O2 Synonym: AZ5104 AZ