AMG 232 Catalog No.:M8600-10 PubMed PMID: 26185454

PubMed PMID: 26185454

is a potent and selective RIPK2 inhibitor which shows NOD signalling events yet prevents inflammatory cytokine production

Smiles: CC(C)(C)C1=CC(C(O)=O)=C(NC(=O)NC2C=C3C=NNC3=CC=2)S1

McCloud RL

AMG 232 Catalog No.:M8600-10 PubMed PMID: 26185454AMG232 is an extremely potent MDM2 inhibitor (SPR KD = 0. 045 nM, SJSA 1 EdU IC50 = 9. 1 nM), with remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA 1 osteosarcoma xenograft model (ED50 = 9. 1 mg kg). AMG232 is currently under clinical development. Product information CAS Number: 1352066 68 2 Molecular Weight: 568. 55 Formula: C28H35Cl2NO5S Synonym: AMG232 AMG 232 Chemical Name: 2 [(3R,5R,6S) 5 (3 chlorophenyl) 6 (4