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BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S These culture conditions do not

BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S These culture conditions do not

Name: BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S These culture conditions do not
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BIBW2992(Afatinib) - EGFR Inhibitor. CAS# 439081-18-2 Catalog No.:M60065-10S These culture conditions do notBIBW2992 (Afatinib), CAS No. 439081 18 2, is a highly potent and selective irreversible EGFR inhibitor, inhibiting EGFRwt, EGFRL858R, EGFRL858R T790M and HER2 with IC50 of 0. 5 nM, 0. 4 nM, 10 nM, 14 nM, respectively. BIBW2992 suppresses transformation in isogenic cell based assays, inhibits survival of cancer cell lines, exhibits potent effects on both EGFR and HER2 phosphorylation, and induces tumor regression in xenograft and transgenic lung cancer

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Description

These culture conditions do not include xenobiotic supplements

4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide

GDC-0068 was orally dosed to mice at 50-100 mg/kg once per day

Elayne Chan-Penebre

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