Tasisulam(LY573636) - CAS# 519055-62-0 060 PKCδ and PKCζ with IC50

PKCδ and PKCζ with IC50 of 7 nM

CAS Number: 1260907-17-2

Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat

Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency

Tasisulam(LY573636) - CAS# 519055-62-0 060 PKCδ and PKCζ with IC50Tasisulam, also known as LY573636, CAS No. 519055 62 0, is an acyl sulfonamide with potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS). In combination with an angiogenesis inhibitor, this agent may exhibit synergistic antiangiogenic activity.