AZD4547 ratriptan 3H)-pyrimidinedione

3H)-pyrimidinedione

PubMed Central PMCID: PMC4275380

It is used as a general solvent and in paints

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AZD4547 ratriptan 3H)-pyrimidinedioneAZD4547 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor AZD4547 binds to and inhibits FGFR, which may result in the inhibition of FGFR related signal transduction pathways, and, so, the inhibition of tumor cell proliferation and tumor cell death. FGFR, up regulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cellular proliferation,