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TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 size:2mg solid Human bone marrow derived mesenchymal

TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 size:2mg solid Human bone marrow derived mesenchymal

Name: TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 size:2mg solid Human bone marrow derived mesenchymal
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SKU: 47052877859
Price: 129.71 USD
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SKU: 47052877859

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TH-302 - Hypoxia-activated Pro-drug. CAS# 918633-87-1 size:2mg solid Human bone marrow derived mesenchymalTH 302, CAS No. 918633 87 1, is a highly potent and selective hypoxia activated pro drug targeting hypoxic regions of solid tumors with an IC50 of 19 nM. It is stable to liver microsomes. However, under hypoxic conditions, it is selectively and irreversibly converted to its active phosphoramidate based, DNA crosslinking, bis alkylator. TH 302 inhibits H460 cells and HT29 cells with IC90 of 0. 1 M and 0. 2 M, respectively. It shows much enhanced

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Description

Human bone marrow derived mesenchymal stem cells from three different donors were treated with Daidzein-2c and shown to exhibit enhanced osteogenesis when compared to daidzein or estrogen treatment

1001264-89-6

3(2H)-dione

4-dihydro-1

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