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TAK-960 - CAS# 1137868-52-0 Catalog No.:M6675-2 There is no formal name

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TAK-960 - CAS# 1137868-52-0 Catalog No.:M6675-2 There is no formal nameTAK 960, CAS No. 1137868 52 0, is a n orally available PLK1 inhibitor with potential antineoplastic activity. Polo like kinase 1 inhibitor TAK 960 selectively inhibits PLK1, inducing selective G2 M cell cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1 overexpressed

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Description

There is no formal name yet

CAS Number: 30675-13-9

is a brain penetrant

PubMed PMID: 21966423

TAK-960 - CAS# 1137868-52-0 Catalog No.:M6675-2 There is no formal nameTAK 960, CAS No. 1137868 52 0, is a n orally available PLK1 inhibitor with potential antineoplastic activity. Polo like kinase 1 inhibitor TAK 960 selectively inhibits PLK1, inducing selective G2 M cell cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1 overexpressed

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