Palovarotene - CAS# 410528-02-8 Catalog No.:M10349-2 PF-03716556 inhibits gastric acid secretion

PF-03716556 inhibits gastric acid secretion in rat and dog models

The tyrosine kinase inhibitor GNF-2 suppresses osteoclast formation and activity

InChi: InChI=1S/2C26H28N3

Vincristine induces mitotic arrest and promots the expression of caspase-3 and -9 and cyclin B

Palovarotene - CAS# 410528-02-8 Catalog No.:M10349-2 PF-03716556 inhibits gastric acid secretionPalovarotene, also known as RO 3300074 and R 667, is a highly selective retinoic acid receptor gamma (RAR ) agonist that is under investigation as a potential treatment for emphysema. Phase I clinical trials of palovarotene in patients with emphysema demonstrated that the drug is well tolerated, with improvements observed in markers of emphysema progression. Emphysema is characterized by the destruction of alveoli and alveolar ducts within the lungs.