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VH 298 20046 Skrepnik N
VH 298 20046 Skrepnik N
VH 298 20046 Skrepnik N
VH 298 20046 Skrepnik N

VH 298 20046 Skrepnik N

SKU: 2625875851

4.6
USD120.00 USD163.00

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VH 298 20046 Skrepnik NVH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85

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Description

Skrepnik N

145888-79-5

Chemical Name:  2-(4-Bromophenyl)-N-(4-fluorobenzyl)-3-propyl-3H-imidazo[4

and inhibits the enzyme with an IC50 of 0

VH 298 20046 Skrepnik NVH 298 is a potent VHL inhibitor that stabilizes HIF and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL: HIF protein protein interaction downstream of HIF hydroxylation by PHD enzymes. VH298 represents a high quality chemical probe of the HIF signalling cascade and an attractive starting point to the development of potential new therapeutics targeting hypoxia signalling. Product information CAS Number: 2097381 85

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