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These opposing effects on bowel habitsconstipation in some individuals and diarrhoea in othersreflect individual variation in how the gastrointestinal system responds to GLP-1 receptor activation

From six months onward, the GLP-1 group was more likely to experience gastroparesis than the control group

For a broader overview, see the AJMC article on oral peptides

Plasma DPP-4 activity and TG excursion were reduced, and plasma active GLP-1 was increased, in sitagliptin-treated Dpp4 +/+ mice, but sitagliptin had no effect in Dpp4 / mice (Figure 1, B and C, and Supplemental Figure 3, A and B), consistent with the selectivity of sitagliptin for DPP-4 (22)