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Short-Term: Reduction in insulin needs, weight loss, improved post-meal glucose levels, improved glucose levels overall, lower blood pressure and lipid levels

(2) Aging and lifestyle factors like pregnancy can result in the development of excess fat in numerous areas

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Moreover, besides binding of minor fraction of Cu(II) ions, His can also act as a catalyst enhancing the rate of the copper transfer between CuHSA and other proteins and cellular destinations, which might be the most important physiological role of His in copper metabolism