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doi: 10.1016/j.cell.2018.10.001 37 YangYTianduoPChaobaoLMingtaoCXiaolinHJieYet al

During oxidative stress, modifications in cysteine residues on Keap1 release Nrf2, allowing it to translocate into the nucleus, bind to AREs in target genes, and initiate transcription of essential antioxidant genes 67

Arbutin acts by competitively inhibiting tyrosinase and inhibiting melanosome maturation Azelaic Acid This naturally occurring dicarboxylic acid is derived from a lipophilic yeast called pityrosporum ovale

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