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Pregnancy increases the risk of uteroplacental thrombosis in a hypercoagulable state because of coagulation factors, regulators, and fibrinolytic system changes

found that in pancreatic cancer patients, the expression of ubiquitin-specific protease 8 (USP8) is increased, and USP8 stabilizes NRF2 expression by deubiquitinating K48-linked polyubiquitin chains on NRF2