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10.1530/EC-21-0187 3 AhrnB

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In mice with high-fat diet-induced hyperglycemia, hyperinsulinemia, and associated induction of TNF, a reduction of GLP-1-secretion was observed, which could be reversed by treatment with the TNF-neutralizing antibody etanercept (95)

"So, this study is an exciting step forward in our understanding of how these new medicines for obesity work." "The findings also provide science to support the fact that the treatment of obesity is not simply to eat less and move morethat's the prevention piece