PA21B Polyclonal Antibody, 50ul Inoculating Loops/Needles Phosphorylated during mitosis

Phosphorylated during mitosis

Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene

Mitogen-activated protein kinase kinase kinase kinase 3 activates key effectors in cell signalling

A related pseudogene has been found on chromosome 6

PA21B Polyclonal Antibody, 50ul Inoculating Loops/Needles Phosphorylated during mitosisThis gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium dependent enzyme catalyzes the hydrolysis of the sn 2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs)