CACB4 Polyclonal Antibody, 100ul Recombinant Ab Production Defects in POU4F3 are the

Defects in POU4F3 are the cause of non-syndromic sensorineural deafness autosomal dominant type 15

The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing| export of mRNAs from the nucleus| protein translation| and mRNA stability

The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP)

Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex

CACB4 Polyclonal Antibody, 100ul Recombinant Ab Production Defects in POU4F3 are theThis gene encodes a member of the beta subunit family of voltage dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha 1, alpha 2 delta, beta, and gamma subunits in a 1: 1: 1: 1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this