Mouse Dickkopf Related Protein 2, DKK2 ELISA Kit, 96T Enzymes The protein encoded by this

The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation

Directly involved in heterochromatin formation by maintaining overall chromatin structure and| in particular| that of constitutive heterochromatin by stabilizing histone methylation

The product of this gene is highly conserved with a mouse protein associated with the cytoplasmic face of late endosomes and lysosomes

This protein is also thought to modify lipid metabolism and insulin-regulated gene expression

Mouse Dickkopf Related Protein 2, DKK2 ELISA Kit, 96T Enzymes The protein encoded by thisAntagonizes canonical Wnt signaling by inhibiting LRP5 6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5 6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone