IKK gamma Polyclonal Antibody, 50ul[BT-AP02164] Peptide Library Origin recognition complex subunit 1

Origin recognition complex subunit 1 contains an OTU domain and binds Ubal (ubiquitin aldehyde)

Both calcium/calmodulin and protein phosphorylation mechanisms control its activity

both anchored in the membrane

Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family| but not in similar patients of European descent

IKK gamma Polyclonal Antibody, 50ul[BT-AP02164] Peptide Library Origin recognition complex subunit 1This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex which activates NF kappaB resulting in activation of genes involved in inflammation immunity cell survival and other pathways. Mutations in this gene result in incontinentia pigmenti hypohidrotic ectodermal dysplasia and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.