Nibrin Polyclonal Antibody, 50ul[BT-AP06020] Recombinant Protein Expression which participates in cell-cycle regulated

which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB

This protein may function in vesicle trafficking| membrane fusion| protein complex assembly and cell motility

This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse

and their phosphorylation is essential for the Catalytic activity of the N-terminal kinase domain

Nibrin Polyclonal Antibody, 50ul[BT-AP06020] Recombinant Protein Expression which participates in cell-cycle regulatedMutations in NBN are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. Nibrin is a member of the MRE11 RAD50 double strand break repair complex which consists of 5 proteins. NBN product is thought to be involved in DNA double strand break repair and DNA damage induced checkpoint activation.