GHR Polyclonal Antibody, 20ul DNA Fragments The type II cytokeratins are

The type II cytokeratins are clustered in a region of chromosome 12q12-q13

recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction

and serves as a scaffold protein in signal transduction

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GHR Polyclonal Antibody, 20ul DNA Fragments The type II cytokeratins areGHR encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature.