Crk II Monoclonal Antibody, 100ul[BT-MCA0386] Custom RNA Oligos Alternate transcription initiation sites result

Alternate transcription initiation sites result in two transcript variants of this gene

The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts

The encoded protein may play an important role in the development of anterior ventral forebrain and visual system

Mutations in this gene have been associated with individuals affected by severe intellectual disability| early-onset epilepsy| microcephaly| congenital cataracts| growth retardation| and spasticity (PMID: 25439727)

Crk II Monoclonal Antibody, 100ul[BT-MCA0386] Custom RNA Oligos Alternate transcription initiation sites resultThis gene encodes a member of an adapter protein family that binds to several tyrosine phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2 phosphotyrosine interaction. The N terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C