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UBP20 Rabbit Polyclonal Antibody, 20ul Pipette Controller Aberrant expression of this gene

SKU: 46323796988

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UBP20 Rabbit Polyclonal Antibody, 20ul Pipette Controller Aberrant expression of this geneThis gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL E3 ligase complex this enzyme deubiquitinates hypoxia inducible factor (HIF) 1 alpha and thereby causes increased expression of HIF 1alpha targeted genes which play a role in angiogenesis glucose metabolism cell proliferation and

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Description

Aberrant expression of this gene may paly a role in tumorigenesis

Three alternatively spliced transcript variants that encode different protein isoforms have been described

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UBP20 Rabbit Polyclonal Antibody, 20ul Pipette Controller Aberrant expression of this geneThis gene encodes a ubiquitin specific processing protease that was first identified as a substrate of the VHL (von Hippel Lindau disease) protein E3 ubiquitin ligase complex. In addition to being ubiquitinated by the VHL E3 ligase complex this enzyme deubiquitinates hypoxia inducible factor (HIF) 1 alpha and thereby causes increased expression of HIF 1alpha targeted genes which play a role in angiogenesis glucose metabolism cell proliferation and

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