Parkin Polyclonal Antibody, 100ul Cell Culture Flasks while CUL-2 associates with the

while CUL-2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes

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suggesting that it has no protease activity

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Parkin Polyclonal Antibody, 100ul Cell Culture Flasks while CUL-2 associates with theThe precise function of PARK2 is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in PARK2 are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of PARK2 produces multiple transcript variants encoding distinct isoforms. Additional splice variants of PARK2 have