TOK-1 Polyclonal Antibody, 100ul Culture Media In vertebrates| sister chromatid cohesion

In vertebrates| sister chromatid cohesion is released in 2 steps via distinct mechanisms

Studies have shown that the inactivated gene is present as the predominant allele in the human population

Mutations in CHEK2 have been linked with Li-Fraumeni syndrome

also known as keratosis follicularis

TOK-1 Polyclonal Antibody, 100ul Culture Media In vertebrates| sister chromatid cohesionBCCIP (BRCA2 and CDKN1A interacting protein) product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N terminal half shares moderate homology with regions of calmodulin and M calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a