Rb(Phospho Ser795) Polyclonal Antibody, 100ul Cryogenic Vials This gene is expressed in

This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia

Mutations in this gene are associated with susceptibility to obesity in humans

May contribute to signal transduction through its intracellular domain

The MALT1 paracaspase encoded by MALT1 may play a role in NF-kappaB activation

Rb(Phospho Ser795) Polyclonal Antibody, 100ul Cryogenic Vials This gene is expressed inThe protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.