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Oral semaglutide is the first oral GLP 1 RA proven to reduce MACE in high risk T2DM patients, extending cardiovascular protection beyond injectable formulations. SOUL Trial: Oral Semaglutide & Cardiovascular Outcomes in T2DM soul semaglutide Congreso ACC. 25: Oral Semaglutide Reduces Cardiovascular Events in People With Type 2 Diabetes With Atherosclerotic Cardiovascular and or Chronic Kidney Disease: Primary Results From the SOUL Randomized Trial FDA Clears Semaglutide For Cardiac Risk Reduction in Diabetic Patients DAIC Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes New England Journal of Medicine
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