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doi: 10.1093/brain/awv350 35 HoriK.KatayamaM.SatoN.IshiiK.WagaS.YodoiJ

These assessments can identify any emerging concerns before they become problematic

However, basal levels of phase I and most phase II drug metabolizing enzymes in HepG2 cells are very low compared to human hepatocytes (Wilkening et al., 2003