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Moreover, GLP-1RAs stimulate endothelial VEGF expression, a fundamental trigger for angiogenesis, leading to activation of downstream VEGF receptors (VEGFR-2), which initiate angiogenic cascades involving phospholipase C gamma/extracellular signal-regulated kinase/phosphoinositide 3-kinase/protein kinase B pathways

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Tirzepatide versus Semaglutide once Weekly in Type 2 diabetes

Typical dosing: .25 mg Week 1-4 .50 mg Week 5-8 .1.0 mg Week 9-12 1.7 mg Week 13-16 2.4 mg Week 17+ Semaglutide injections are applied subcutaneously (very comfortably just under the skin with a tiny needle like insulin) once a week, any time of day, with or without food