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Dipeptidyl peptidase 4 inhibitors with gliptin-like structures, based on approved and published data, are generally classified into three groups: (a) Compounds with a pyrrolidine as the S 1 -binding segment connected by an aminoacyl spacer, (b) those containing trifluorophenyl derivatives as the S 1 -binding segment with an -aminobutanoyl spacer, and (c) structures featuring pyrimidine-2,4-dione or its analogs as the S 1 -binding segment

however, its selectivity toward GLS1 and failure to inhibit the compensatory effect of GLS2 require in-depth study 14

Significant health issues may result such as diabetes, heart disease, and high blood pressure

Factors like age, weight, climate, and physical activity level all play a role