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Furthermore, pretreatment of cultures with liraglutide attenuated measures of synapse induced by A oligomers (AOs), but liraglutide failed to prevent AOs-induced synapse loss after treated PKA inhibitor, and liraglutide attenuated the AOs-induced decrease of PKA activity, suggesting that activation of the cAMP/PKA pathway underlies the neuroprotective actions of liraglutide (176)

The authors noted that this compares favorably with estimates reported for approved medications, which are typically 7 or higher for the same endpoint

Additionally, the spray mechanism itself allows for precise micro-dosing, ideal for dose-response modeling in exploratory glucose regulation studies

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