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Tolerance often depends on dose, how quickly doses are increased, and personal sensitivity

12 Building on these results, the SCALE Maintenance trial demonstrated that the combination of liraglutide 3.0 mg per day and lifestyle intervention significantly improved weight maintenance at 56 weeks when compared with controls (who received placebo and lifestyle intervention) in overweight and obese individuals who had already lost at least 5% of initial body weight during a low-calorie diet prior to randomization

Patients must take oral semaglutide on an empty stomach with no more than 4 ounces of plain water only, swallow the tablet whole, and wait at least 30 minutes before eating, drinking, or taking any other oral medications to optimize absorption

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