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1), their potential influence on stem cells biology, especially human mesenchymal stem cells (hMSC) are not yet fully understood

They generated inducible OL knockouts by crossing proteolipid protein 1-Cre recombinase-estrogen receptor T2 (Plp1-CreERT2) with Gipr floxed mice, triggered recombination with tamoxifen at postnatal day 60, and induced obesity with a 60% high-fat diet