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Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration: The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial

Interestingly, most of the differentially expressed CSEPs were represented in only four clusters (clusters 1, 4, 5 and 7), all of which show peak expression in the mid and/or late stages of disease development ( Figure 4 )

To further account for heterogeneity in the populations, interventions, and outcome definitions reported in the included meta-analyses, we performed a stratified synthesis